
How do cells regulate their genomes?
We are fascinated with understanding how cells organize, protect, and segregate their genomes and how these processes can be rewired across different cellular contexts. To answer these questions we use mammalian cell lines and a combination of high-resolution imaging, functional genetics, and large-scale screens. Our approach is to harness the context-specific gene requirements that are intrinsic to organismal function as a key to unraveling the mechanisms that govern chromosome biology and define how alterations in core cellular processes influence disease, development, and evolution.
We had a blast celebrating Labsgiving with the Moore and Kang labs! After an intense round of Family Feud, we are proud to announce that our team emerged victorious!! The trophy will be proudly displayed in our lab for all to see.
Better luck next year to the rival team – we’ll be waiting to defend our title and the coveted trophy! ๐
Thanks to everyone who came out to celebrate, eat great food, and bring the competitive spirit. Same time next year?
Happy birthday, Molly! We had a blast celebrating you today. Thank you for being such an amazing member of our team ๐
We’re thrilled to share that our research is featured in Colorado Biosciences Magazine, with our lab on the cover! This work, supported by the Boettcher Webb-Waring Biomedical Research Award, highlights our team’s ongoing efforts to understand the role of PRR12 and the Cohesin complex in the repair of damaged DNA and how alterations to these proteins contribute to disease. We’re grateful to the Boettcher Foundation for their generous support, which makes this important work possible.
We’re thrilled to welcome Colette Hopkins, who will be rotating with our lab this winter semester! Colette is a graduate student in the Cells, Stem Cells, and Development Graduate Program with a keen interest in understanding how cells respond to prolonged mitotic stress. During her rotation, Colette will investigate the mechanisms cells employ to cope with extended stress and work to identify the proteins that become essential for survival under these conditions. Welcome to the lab, Colette!
We’re diving into exciting new waters! ๐๐ฌ We’ve teamed up with the Nelson lab here at CU Anschutz to investigate PRR12’s role during early development using the zebrafish model system. These tiny embryos are helping us uncover what this gene does during early development, if it relates to its role in regulating Cohesin function, and why mutations in this gene lead to a variety of developmental disorders. Stay tuned for more discoveries!
We’re excited to welcome Sean to the lab! Sean is a first-year graduate student in the Cell Biology, Stem Cells, and Development (CSD) program who’s rotating with us through November. During his rotation, he’ll be investigating how PRR12 functions in development and exploring how mutations in this gene contribute to disease. Welcome, Sean!




We are thrilled to represent the University of Colorado, Anschutz Medical school as a recipient of the Boettcher Webb-Waring Biomedical Research Award. This grant will support our work exploring the role of PRR12 in the regulation of the Cohesin complex in the repair of damaged DNA.




Michael is joining our team as a Professional Research Assistant. Michael completed his undergraduate training at Trinity University in San Antonio Texas, where he studied plant and fungi interactions in the lab of Dr. Kelly Lyons. Michael will be spearheading our work exploring gene requirement changes across species. We are excited to have Michael as part of the team!

We are excited to present our latest work on PRR12 at the 2024 ASCB conference in San Diego. Come visit Ally who will be presenting our poster “Co-Essentiality Analysis Identifies PRR12 as a Regulator of Cohesin and Genome Integrity” on Monday Dec 16, 2024 from 11:15 AM – 3:00 PM. We are at Board number B277 in the DNA Damage and Repair session.
Molly is joining us as a postdoc from Fred Hutch Cancer Center where she recently completed her PhD in the lab of Emily Hatch. Molly is an expert in chromatin regulation and a skilled microscopist. Molly will be exploring the role of PRR12 and Cohesin in the DNA damage response. We are excited to have Molly as part of the team and look forward to seeing all of the pretty images to come from her future work!

We welcome applications from potential postdoctoral fellows. Please email Ally with a short research description, CV, and contact information for 3 references.
CU graduate students can join the lab through a rotation. Please contact Ally to learn more about rotation opportunities.


University of Colorado School of Medicine
Department of Cell and Developmental Biology
Research 1 South, Room 12113
12801 E. 17th Ave
Aurora, CO 80045