How do cells regulate their genomes?
Our Big Question:
We are fascinated with understanding how cells organize and segregate their genomes and how these processes can be rewired across different cellular contexts. To answer these questions we use mammalian cell lines and mouse models and a combination of high-resolution imaging, functional genetics, and large-scale screens. Our approach is to harness the context-specific gene requirements that are intrinsic to organismal function as a key to unraveling the mechanisms that govern chromosome biology and define how alterations in core cellular processes influence disease, development, and evolution.
News!
- Visit us at ASCB!
We are excited to present our latest work on PRR12 at the 2024 ASCB conference in San Diego. Come visit Ally who will be presenting our poster “Co-Essentiality Analysis Identifies PRR12 as a Regulator of Cohesin and Genome Integrity” on Monday Dec 16, 2024 from 11:15 AM – 3:00 PM. We are at Board number B277 in the DNA Damage and Repair session.
- Welcome Molly Zych to the lab!
Molly is joining us as a postdoc from Fred Hutch Cancer Center where she recently completed her PhD in the lab of Emily Hatch. Molly is an expert in chromatin regulation and a skilled microscopist. We are excited to have Molly as part of the team and look forward to seeing all of the pretty images to come from her future work!
Join Us
Postdoctoral Fellows
We welcome applications from potential postdoctoral fellows. Please email Ally with a short research description, CV, and contact information for 3 references.
Graduate Students
CU graduate students can join the lab through a rotation. Please contact Ally to learn more about rotation opportunities.
Contact Us
University of Colorado School of Medicine
Department of Cell and Developmental Biology
Research 1 South
12801 E. 17th Ave
Aurora, CO 80045